1.5萬字            34頁

摘要  由于環(huán)糊精有外沿親水而內(nèi)腔疏水的結(jié)構(gòu)，因而它能夠作為主體來包絡(luò)各種適當(dāng)?shù)目腕w，這使得環(huán)糊精水凝膠在藥物釋放、溫度敏感性、pH敏感性、多（雙）重敏感性等方面具有廣泛的應(yīng)用?；诃h(huán)糊精水凝膠的廣泛應(yīng)用，本文通過實(shí)驗(yàn)來制備溫敏性環(huán)糊精微凝膠，同時(shí)對制備的微凝膠進(jìn)行釋放性能的研究。本文主要以β-環(huán)糊精為原料，使用丙烯酸將β-環(huán)糊精改性，再制備出β-環(huán)糊精微凝膠，完成后，再將β-環(huán)糊精微凝膠表面溴化，使用N–異丙基丙烯酰胺在環(huán)糊精微凝膠表面接枝上聚異丙基丙烯酰胺，最終成功合成至溫敏性環(huán)糊精水凝膠。完成試驗(yàn)后，對產(chǎn)品進(jìn)行表征和分析，測定產(chǎn)物的紅外光譜圖，進(jìn)行元素分析和熱綜合分析等。分析數(shù)據(jù)表明，本實(shí)驗(yàn)成功制備出了溫敏性環(huán)糊精微凝膠，并且制備出的產(chǎn)物具有良好的熱穩(wěn)定性。最后本實(shí)驗(yàn)測試了亞甲基藍(lán)在溫敏性微凝膠中釋放的行為，結(jié)果表明，實(shí)驗(yàn)制備的溫敏性環(huán)糊精微凝膠具有良好的溫度敏感性，并且具有良好的可逆可控釋放性能。

關(guān)鍵詞：β-環(huán)糊精  水凝膠  丙烯酸  溫敏性能

preparation of Temperature Sensitive cyclodextrin microgel and Its Releasing property

Abstract  Cyclodextrins have outside along the hydrophilic and hydrophobic of inner chamber structure, it can be used as the main envelope all appropriate object，which makes the drug cyclodextrin hydrogels release, temperature sensitivity, pH sensitivity multi (dual) weight sensitivity has a wide range of applications. In order to synthesize cyclodextrins temperature sensitive microgels ,we use acrylic  cyclodextrin modified, β- cyclodextrin esterified to the crylic -β- cyclodextrin ester, then, the crylic -β- cyclodextrin ester is produced into β- cyclodextrin cyclodextrin. After the completion of the experiment, we use N - methyl pyrrolidone at the β- cyclodextrin microgels bromide at 0 ℃.Then we add a certain amount N- isopropyl acrylamide in the product, and through experiments, poly-isopropyl acrylamide is grafted onto the surface of the cyclodextrin microgel, thereby we success to prepare temperature sensitive cyclodextrin microgel. After completing the test, the products are characterized and analyzed, the measurement result of infrared spectrum, element analysis and heat comprehensive analysis, etc. Data analysis shows that the experiment successful prepares thermosensitive microgel cyclodextrin, and the product has good thermal stability. Finally, the experiment tested methylene blue released behavior in the temperature-sensitive microgel , the results show that the products has good temperature sensitivity, and they has a good reversible controlled release performance.

Key words: β- cyclodextrin   Hydrogels   Acrylic acid   Thermosensitivity 

  

第一章 緒論

1 環(huán)糊精研究概況

1.1 環(huán)糊精簡介

環(huán)糊精(Cyclodextrin，簡稱CD)是直鏈淀粉在由芽孢桿菌產(chǎn)生的環(huán)糊精葡萄糖基轉(zhuǎn)移酶的作用下生成的一系列的環(huán)狀低聚糖的總稱，通常含有6~12個(gè)D-吡喃葡萄糖單元。其中，含有6、7、8個(gè)葡萄糖單元的分子的環(huán)糊精研究較多并且具有實(shí)際意義，它們分別稱為α-、β-和γ-環(huán)糊精(化學(xué)式:C14H8O2)，構(gòu)成環(huán)糊精分子的每個(gè)D(+)-吡喃葡萄糖都是椅式構(gòu)象，各葡萄糖單元均以1，4-糖苷鍵結(jié)合成環(huán)。環(huán)糊精分子不是圓筒狀分子而是略呈錐形的圓環(huán)，這是因?yàn)檫B接葡萄糖單元的糖苷鍵不能自由旋轉(zhuǎn)