全腸外營(yíng)養(yǎng)制劑的穩(wěn)定性研究及改善措施

摘要：本文主要通過對(duì)影響全腸外營(yíng)養(yǎng)制劑穩(wěn)定性因素的研究，得到保持TPN穩(wěn)定應(yīng)采取的改善措施，從而為臨床上全腸外營(yíng)養(yǎng)制劑合理處方的設(shè)計(jì)提供依據(jù)。研究分析了影響腸外營(yíng)養(yǎng)液穩(wěn)定性的因素：脂肪乳、維生素、微量元素的不穩(wěn)定性；不溶性微粒的變化；三升袋的吸附、菮@鱟饔靡約安辛艨掌撓跋臁７治鱟芙岣納拼朧┑貿(mào)黿崧郟何３諸PN的穩(wěn)定，應(yīng)在配置、儲(chǔ)藏以及使用時(shí)進(jìn)行各項(xiàng)檢查，注意是否有配伍禁忌的情況出現(xiàn)，控制好各組分的量，并正確選擇貯存袋、鈣劑和磷劑；在配置過程中，應(yīng)注意PH值、電解質(zhì)等的影響，以正確的混合順序去配置；在配置后，應(yīng)注意排除三升袋中殘留的空氣，避免光線對(duì)營(yíng)養(yǎng)液的照射，同時(shí)也要注意存放的時(shí)間不能太長(zhǎng)等等。由于技術(shù)的有限性，影響腸外營(yíng)養(yǎng)液穩(wěn)定性的其他因素尚未發(fā)現(xiàn)，還需進(jìn)一步完善，來保證TPN的質(zhì)量及臨床使用安全有效。
關(guān)鍵詞：腸外營(yíng)養(yǎng)；穩(wěn)定性；研究分析；改善措施

　　　Stability study and improvement measures of TPN
　
Abstract: This paper mainly through the research on the influence factors of total parenteral nutrition preparation stability, maintain TPN stability should take measures to improve, so as to provide the basis for the design of total parenteral nutrition preparation reasonable prescription in clinic. Analysis of the factors affecting the stability of parenteral nutrition: unstable fat milk, vitamins, trace elements; insoluble particle adsorption, change; three liters bag stripping functions and effects of residual air. Conclusion: summary and analysis of improvement measures to maintain the stability of the TPN, should carry out the inspection in the configuration, storage and use, pay attention to whether appear incompatible situation, control components, and the correct choice of storage bag, calcium and phosphorus agent; in the configuration process, should pay attention to the impact of pH, electrolyte so, in order to correct the hybrid configuration; configuration, should pay attention to rule out three liter bags in the residual air, avoid exposure to light of the nutrient solution, also want to pay attention to storage time not too long. Because of the limitation of technology, other factors affecting the stability of parenteral nutrition has not been found, still need further perfect, to ensure safe and effective TPN quality and clinical use.
Keywords: parenteral nutrition; stability; analysis; improvement measures