松茸多糖對(duì)輻射損傷小鼠免疫功能的防護(hù)作用研究

[摘要]目的：觀察松茸多糖對(duì)輻射損傷小鼠各項(xiàng)免疫指標(biāo)的影響，探討松茸多糖對(duì)輻射損傷小鼠免疫功能的防護(hù)作用。 方法：將ICR小鼠隨機(jī)分成三組：正常對(duì)照組（NC），輻射對(duì)照組（IC）及松茸多糖組（PTM）。PTM組按800mg/kg劑量給予小鼠灌胃，每天一次，連續(xù)十一天。第七天除NC組小鼠外給予一次性2.0Gy X射線照射。末次灌胃后第二天將小鼠處死，檢測(cè)白細(xì)胞數(shù)，脾、胸腺細(xì)胞數(shù)，脾、胸腺系數(shù)，脾細(xì)胞對(duì)ConA刺激指數(shù)（SI）。  結(jié)果：IC組與NC組相比，白細(xì)胞計(jì)數(shù)，脾、胸腺細(xì)胞計(jì)數(shù)，脾、胸腺系數(shù)，脾細(xì)胞刺激指數(shù)（SI）均有顯著性降低（p<0.05）。PTM組與IC組相比，白細(xì)胞計(jì)數(shù)，脾、胸腺細(xì)胞計(jì)數(shù)，脾、胸腺系數(shù)，脾細(xì)胞刺激指數(shù)（SI）均有顯著性增高（p<0.05）。 結(jié)論：松茸多糖對(duì)輻射損傷小鼠免疫功能具有防護(hù)作用。

[關(guān)鍵詞]：松茸多糖；輻射損傷；免疫功能

Study on the immunity protective effect of PTM 

in irradiated mice

 (School of Public Health, Jilin University, Changchun, 130021)

[Abstract] Objective: To observe the immunity protective effect of polysaccharide of tricholoma matsutake (PTM) in irradiated mice。 Methods: The ICR mice were randomly divided into three groups：normal control group（NC）,irradiated control group（IC）, polysaccharide of tricholoma matsutake group (PTM) . The PTM group was administered by intragastric administration with a dose of 800mg/kg for 11 d . All groups except NC group were irradiated once with 2.0Gy X-ray on 7th. Immunity parameters including the number of WBC、 spleen 、thymus gland cells, the organ coefficient of spleen、thymus gland and SI were observed on 6th day after irradiation.   Results: The number of WBC、 spleen 、thymus gland cells, the organ coefficient of spleen、thymus gland and SI of PTM group were higher than that in IC group. There was a significant difference between PTM group and IC group(p<0.05).  Conclusion: PTM has the immunity protective effect in irradiated mice.

[Keywords] polysaccharide of tricholoma matsutake（PTM）；radiation breakdown；immunity